An isoleucine zipper peptide forms a native-like triple stranded coiled coil in solution

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An isoleucine zipper peptide forms a native-like triple stranded coiled coil in solution.

Recent studies in the field of de novo protein design have focused on the construction of native-like structures. Here we describe the design and characterization of an isoleucine zipper peptide intended to form a parallel triple-stranded coiled coil. To obtain the native-like structural uniqueness, the hydrophobic interface of the peptide consists of beta-branched Ile residues for complementar...

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ژورنال

عنوان ژورنال: Protein Engineering Design and Selection

سال: 1998

ISSN: 1741-0126,1741-0134

DOI: 10.1093/protein/11.11.1051